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Blueprint Medicines
Cambridge, Massachusetts, United States
8 days ago


Scientist II, Process Chemistry Research & Development

Cambridge, MA

Requisition Number: 201

Blueprint Medicines is a global precision therapy company that invents life-changing therapies for people with cancer and hematologic disorders. Applying an approach that is both precise and agile, we create medicines that selectively target genetic drivers, with the goal of staying one step ahead across stages of disease. Since 2011, we have leveraged our research platform, including expertise in molecular targeting and world-class drug design capabilities, to rapidly and reproducibly translate science into a broad pipeline of precision therapies. Today, we are delivering approved medicines directly to patients in the United States and Europe, and we are globally advancing multiple programs for genomically defined cancers, systemic mastocytosis, and cancer immunotherapy.

What will you do?

Blueprint Medicines is seeking an outstanding candidate for a Scientist II in Process Chemistry R&D. This candidate will be responsible for the planning and execution of all activities related to the development and manufacturing oversight of small molecule API. This includes contributing to the integration of CMC plans from pre-IND/IMPD through NDA/MAA in support of Blueprint Medicines’ pre-clinical and clinical programs.

What will be your responsibilities?

Blueprint Medicines seeks an exceptional candidate for the position of Scientist II, Process Chemistry Research and Development.  This position will report into the Associate Director of Process Chemistry R&D. The right candidate will possess an in-depth understanding of small molecules DS-related activities.

  • Oversee the design, planning, and execution of multi-step organic syntheses of small molecules as a member of cross-functional development teams
  • Support drug substance scale-up, GLP, and GMP manufacturing activities
  • Work with internal and external teams, as well as preferred Contract Development and Manufacturing Organizations (CDMOs) to efficiently design and deliver high quality chemical processes for API delivery
  • Work closely with Medicinal Chemists to ensure synthetic route, pharmaceutical form, and compound properties are appropriate for development
  • Represent Process Chemistry R&D on CMC Subteams
  • Proactively work to manage vendors with regard to scope, timelines, and deliverables
  • Drafting and reviewing of technical and GMP documents, scientific manuscripts, CMC-regulatory documents for regulatory filings and patent applications

What basic qualifications do we require?

  • Master’s or Bachelor’s degree in organic chemistry, in addition to 5 years of applicable experience in a pharmaceutical or biotechnology industry role is required


  • PhD (or Postdoc) in organic chemistry in addition to 2 years of experience in a pharmaceutical or biotechnology industry role is required

What additional qualifications are we seeking?

  • Experience with early phase route development and process optimization
  • Experience with technology transfer and outsourced work on process development, kilo-lab preparation, and plant production
  • Experience in API manufacturing associated with small molecules in clinical development
  • Management of drug substance development and manufacture under an outsourcing model
  • Provides scientific guidance to CMO’s on the assigned programs; helps trouble-shooting development and production issues.
  • Management of on-time API deliveries for drug safety studies, formulation development, preclinical, and clinical studies
  • Preparation of CMC documents suitable for regulatory and/or patent filings.
  • At home in a results-driven, highly accountable environment where you can make a clear impact
  • A team player, who listens effectively and invites response and discussion
  • A collaborator who communicates in an open, clear, complete, timely and consistent manner

COVID-19 Vaccination Requirement

As a biotechnology organization, it is our responsibility to do everything we can to safeguard the health and safety of our workforce, our communities, and the patients we serve.  That is why we require all employees to be fully vaccinated against COVID-19, unless we approve an exemption through a reasonable accommodation for certified health reasons or sincerely held religious beliefs.  Accommodation requests for either of these reasons should be made to

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires an accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to 

For more information, please see our EEO-AA-Policy-Statement, the EEO Poster and its Supplement, as well as our Pay Transparency Statement

Who we are:

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us matters and that our success depends on our ability to work together in a diverse community.  We believe we are at our best as a company when our employees are thriving and we foster a culture that provides opportunities to grow and develop professionally, while also having fun.

Job Information

  • Job ID: 62012302
  • Location:
    Cambridge, Massachusetts, United States
  • Position Title: Scientist II, Process Chemistry Research & Development
  • Company Name For Job: Blueprint Medicines
  • Job Function: Chemist
  • Job Type: Full-Time
  • Job Duration: Indefinite
  • Min Education: BA/BS/Undergraduate
  • Min Experience: 2-3 Years

Please refer to the company's website or job descriptions to learn more about them.

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